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Protein-coding gene in the species Homo sapiens
Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene .[ 5]
FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[ 6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[ 6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[ 6]
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