GNB1

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Vezujući protein guaninskog nukleotida, podjedinica beta-1
PDB prikaz baziran na 1a0r.
Dostupne strukture
2QNS, 3KJ5
Identifikatori
Simbol	GNB1
Vanjski ID	OMIM: 139380 MGI: 95781 HomoloGene: 55532
Ontologija gena Molekularna funkcija • vezivanje G-protein spregnutog receptora • aktivnost GTPaza • aktivnost prenosa signala • GTP vezivanje Celularna komponenta • fotoreceptorski spoljašnji segment • intracelularni • membranska frakcija • heterotrimerni G-proteinski kompleks • ćelijska membrana Biološki proces • metabolički proces energijske rezerve • GTP katabolički proces • prenos signala • signalni put adenilat ciklazom aktiviranog dopaminskog receptora • signalni put fosfolipazom C aktivating G protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	n/a	14688
Ensembl	ENSG00000078369	ENSMUSG00000029064
UniProt	P62873	P62874
RefSeq (mRNA)	NM_002074.3	NM_001160016.1
RefSeq (protein)	NP_002065.1	NP_001153488.1
Lokacija (UCSC)	Chr 1: 1.72 - 1.82 Mb	Chr 4: 154.87 - 154.93 Mb
PubMed pretraga	n/a	[1]

Vezujući protein guaninskog nukleotida G(I)/G(S)/G(T) podjedinica beta-1 je protein koji je kod ljudi kodiran GNB1 genom.

Heterotrimerni vezujući protein guaninskog nukleotida (G proteina), koji integrišu signale između receptora i efektorskih proteina, se sastoje od alfa, beta, i gama podjedinice. Te podjedinice su kodirane familijama srodnih gena. Ovaj gen kodira beta podjedinicu, koja je regulator alfa podjedinica, kao i pojedinih receptora i efektora. Ovaj gen koristi alternativne signale poliadenilacije.

Interakcije

GNB1 formira interakcije sa GNG4.

Literatura

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• Codina J, Stengel D, Woo SL, Birnbaumer L (1986). „Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical”. FEBS Lett. 207 (2): 187–92. DOI:10.1016/0014-5793(86)81486-7. PMID 3095147. 
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• Sondek J, Bohm A, Lambright DG i dr.. (1996). „Crystal structure of a G-protein beta gamma dimer at 2.1A resolution”. Nature 379 (6563): 369–74. DOI:10.1038/379369a0. PMID 8552196. 
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• Mattingly RR, Macara IG (1996). „Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits”. Nature 382 (6588): 268–72. DOI:10.1038/382268a0. PMID 8717044. 
• De Waard M, Liu H, Walker D i dr.. (1997). „Direct binding of G-protein betagamma complex to voltage-dependent calcium channels”. Nature 385 (6615): 446–50. DOI:10.1038/385446a0. PMID 9009193. 
• Huang CL, Jan YN, Jan LY (1997). „Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels”. FEBS Lett. 405 (3): 291–8. DOI:10.1016/S0014-5793(97)00197-X. PMID 9108307. 
• Yu W, Andersson B, Worley KC i dr.. (1997). „Large-scale concatenation cDNA sequencing”. Genome Res. 7 (4): 353–8. DOI:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
• Qin N, Platano D, Olcese R i dr.. (1997). „Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors”. Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866–71. DOI:10.1073/pnas.94.16.8866. PMC 23172. PMID 9238069. 
• Nishida K, Kaziro Y, Satoh T (1999). „Association of the proto-oncogene product dbl with G protein betagamma subunits”. FEBS Lett. 459 (2): 186–90. DOI:10.1016/S0014-5793(99)01244-2. PMID 10518015. 
• Huang L, Shanker YG, Dubauskaite J i dr.. (2000). „Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium”. Nat. Neurosci. 2 (12): 1055–62. DOI:10.1038/15981. PMID 10570481. 
• Carman CV, Barak LS, Chen C i dr.. (2000). „Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2”. J. Biol. Chem. 275 (14): 10443–52. DOI:10.1074/jbc.275.14.10443. PMID 10744734.