IRNK (nukleozid-2'-O-)-metiltransferaza
| iRNK (nukleozid-2'-O-)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.57 | ||||||||
| CAS broj | 61970-02-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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iRNK (nukleozid-2'-O-)-metiltransferaza (EC 2.1.1.57, informacioni ribonukleatni nukleozid 2'-metiltransferaza, informacioni RNK (nukleozid-2'-)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:iRNK (nukleozid-2'-O)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + m7G5'ppp5'R-iRNK S-adenozil-L-homocistein + m7G5'ppp5'Rm-iRNK
Nukleozid pored terminalnog guanozina može da bude bilo guanozin ili adenozin. Formiranje 2'-O-metiladenozinske kape je ranije bilo klasifikovano kao EC 2.1.1.58.
- ↑ Barbosa, E. and Moss, B. (1978). „mRNA(nucleoside-2′-)-methyltransferase from vaccinia virus. Purification and physical properties”. J. Biol. Chem. 253: 7692-7697. PMID 701281.
- ↑ Barbosa, E. and Moss, B. (1978). „mRNA(nucleoside-2′-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity”. J. Biol. Chem. 253: 7698-7702. PMID 701282.
- ↑ Boone, R.F., Ensinger, M.J. and Moss, B. (1977). „Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus”. J. Virol. 21: 475-483. PMID 833934.
- ↑ Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. (1975). „Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus”. Proc. Natl. Acad. Sci. USA 72: 2525-2529. PMID 1058472.
- ↑ Groner, Y., Gilbao, E. and Aviv, H. (1978). „Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates”. Biochemistry 17: 977-982. PMID 629955.
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