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Protein-coding gene in the species Homo sapiens
Potassium channel, subfamily K, member 13 (KCNK13 ), also known as K2P 13.1 or THIK-1, is a protein that in humans is encoded by the KCNK13 gene . It is a potassium channel containing two pore-forming P domains.[ 5] [ 6]
Ribbon structure of homodimeric two-pore potassium channel K2P13 (THIK-1).[ 7] K2P 13.1 was first discovered in 2000 from a rat cDNA library , along with the closely related protein K2P 12.1 [ 5] + channel 1 and 2 (THIK-1 and THIK-2) because the anesthetic halothane inhibited the potassium current. THIK-1 was also shown to be activated by arachidonic acid and displayed mild voltage dependence, with moderate outward rectification at low external K+ and weak inward rectification with nearly symmetrical K+ concentrations.[ 5] [ 8] G-protein-coupled receptor pathways[ 9] lipids such as PIP2 and oleoyl-CoA .[ 10]
In humans, THIK-1 expression is almost exclusively restricted to microglia , where it functions as the main potassium channel and is responsible for maintaining their resting membrane potential through tonic background potassium conductance.[ 11] NLRP3 inflammasome activation, and subsequent release of pro-inflammatory cytokine interleukin-1β (IL-1β) .[ 12] [ 13] [ 14] [ 15]
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