Kobaltohelataza
| Kobaltohelataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 6.6.1.2 | ||||||||
| CAS broj | 81295-49-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kobaltohelataza (EC 6.6.1.2, birnovodonična kiselina a,c-diamidna kobaltohelataza, CobNST, CobNCobST) je enzim sa sistematskim imenom birnovodonična kiselina-a,c-diamid:kobalt kobalt-ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + birnovodonična kiselina a,c-diamid + Co2+ + H2O ADP + fosfat + kob(II)irinska kiselina a,c-diamid + H+
Ovaj enzim učestvuje u aerobnoj biosintezi kobalamina.
Reference
[уреди | уреди извор]- ^ Debussche, L., Couder, M., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F. (1992). „Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans”. J. Bacteriol. 174: 7445—7451. PMID 1429466.
- ^ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390—412. PMID 12195810.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Cobaltochelatase на US National Library of Medicine Medical Subject Headings (MeSH)
