LP-12

LP-12
(IUPAC) ime
	4-(2-difenil)-N-(1,2,3,4-tetrahidronaftalen-1-il)-1-piperazinheksanamid
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	23643664
Hemijski podaci
Formula	C32H39N3O
Mol. masa	481,670 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C32H39N3O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36) ; Key: NMZIDFFHGCRAJV-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

LP-12 je lek koji deluje kao potentan agonist 5HT₇ serotoninskog receptora, se veoma visokom selektivnošću u odnosu na druge receptore, kao što su serotonin 5-HT_1A i 5-HT_2A, i dopaminski D₂ receptor. On je korišten u istraživanjima uloge 5-HT₇ receptor u procesima koji još uvenk nisu dovoljno razjašnjeni, kao što su alodinija i hiperalgezija.^[3]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V (March 2011). „Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia”. Pain 152 (3): 687–97. DOI:10.1016/j.pain.2010.12.020. PMID 21239110.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid21239110-3] Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V (March 2011). „Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia”. Pain 152 (3): 687–97. DOI:10.1016/j.pain.2010.12.020. PMID 21239110.

[1]

[2]

[3]