MBOAT5

MBOAT5
Identifikatori
Aliasi	LPCAT3
Vanjski ID-jevi	OMIM: 611950 MGI: 1315211 HomoloGene: 14678 GeneCards: LPCAT3
EC broj	2.3.1.23
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	7,018,477 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	124,681,381 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • 1-acylglycerophosphocholine O-acyltransferase activity; • acyltransferase activity; • 2-acylglycerol-3-phosphate O-acyltransferase activity; • 1-acylglycerol-3-phosphate O-acyltransferase activity;
Ćelijska komponenta	• integral component of membrane; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum;
Biološki proces	• phosphatidylserine acyl-chain remodeling; • phosphatidylethanolamine acyl-chain remodeling; • phosphatidylcholine acyl-chain remodeling; • regulation of plasma lipoprotein particle levels; • lipid metabolism; • phospholipid biosynthetic process; • phospholipid metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	10162
	14792
	ENSG00000111684
	ENSMUSG00000004270
	Q6P1A2
	Q91V01
	NM_005768
	NM_145130
	NP_005759
	NP_660112
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Lizofosfolipid-aciltransferaza 5 je enzim koji je kod ljudi kodiran genom LPCAT3.^[5]^[6]^[7]^[8]

Homologan je sa drugim O-aciltransferazama vezanim za membranu.

Pregled

Ljudski hromosom 12 sadrži više od 1.400 kodirajućih gena i 487 lokusa koji su direktno uključeni u ljudske bolese. Dugi (q) krak hromooma 12 sadrži jedan od najvećih blokova neravnoteže povezivanja koji se nalazi u ljudskom genomu. Gotova sekvencu ljudskog hromosoma 12, koja je dovršena do visokog kvaliteta i obuhvata približno 132 megabaze, što predstavlja približno 4,5% ljudskog genoma. Poravnavanje sekvence ljudskog hromosoma 12 sa kičmenjacima otkriva porijeklo pojedinačnih segmenata kod kokoši i jedinstvenu historiju preuređivanja putem loza glodara i primata. Stopa zamjena nukleotida u novijoj evolucijskoj povijesti pokazuje opće usporavanje u hominida u odnosu na primate i glodare.

Nakon završetka nacrta sekvence ljudsog genoma, Međunarodni konzorcij za sekvenciranje ljudskog genoma nastavio je s dovršavanjem i označavanjem svakog od 23 hromosoma koji čine ljudski genom.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 487 aminokiselina, a molekulska težina 56.035 Da.^[9]

10	20	30	40	50
MASSAEGDEG	TVVALAGVLQ	SGFQELSLNK	LATSLGASEQ	ALRLIISIFL
GYPFALFYRH	YLFYKETYLI	HLFHTFTGLS	IAYFNFGNQL	YHSLLCIVLQ
FLILRLMGRT	ITAVLTTFCF	QMAYLLAGYY	YTATGNYDIK	WTMPHCVLTL
KLIGLAVDYF	DGGKDQNSLS	SEQQKYAIRG	VPSLLEVAGF	SYFYGAFLVG
PQFSMNHYMK	LVQGELIDIP	GKIPNSIIPA	LKRLSLGLFY	LVGYTLLSPH
ITEDYLLTED	YDNHPFWFRC	MYMLIWGKFV	LYKYVTCWLV	TEGVCILTGL
GFNGFEEKGK	AKWDACANMK	VWLFETNPRF	TGTIASFNIN	TNAWVARYIF
KRLKFLGNKE	LSQGLSLLFL	ALWHGLHSGY	LVCFQMEFLI	VIVERQAARL
IQESPTLSKL	AAITVLQPFY	YLVQQTIHWL	FMGYSMTAFC	LFTWDKWLKV
YKSIYFLGHI	FFLSLLFILP	YIHKAMVPRK	EKLKKME

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111684 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004270 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (Sep 1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.
^ Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (maj 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
^ Zhao Y, Chen YQ, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G (Mar 2008). "Identification and characterization of a major liver lysophosphatidylcholine acyltransferase". J Biol Chem. 283 (13): 8258–65. doi:10.1074/jbc.M710422200. PMID 18195019.
^ "Entrez Gene: MBOAT5 membrane bound O-acyltransferase domain containing 5".
^ "UniProt, Q6P1A2". Pristupljeno 11. 8. 2021.

Dopunska literatura

Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Maurel-Zaffran C, Chauvet S, Jullien N, et al. (1999). "nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis". Mech. Dev. 86 (1–2): 159–63. doi:10.1016/S0925-4773(99)00105-7. PMID 10446276. S2CID 5793636.

Vanjski linkovi

LPCAT3 lokacija ljudskog genoma UCSC Genome Browser.

LPCAT3 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111684 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004270 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8723724-5] Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (Sep 1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.

[pmid9074930-6] Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (maj 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.

[pmid18195019-7] Zhao Y, Chen YQ, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G (Mar 2008). "Identification and characterization of a major liver lysophosphatidylcholine acyltransferase". J Biol Chem. 283 (13): 8258–65. doi:10.1074/jbc.M710422200. PMID 18195019.

[entrez-8] "Entrez Gene: MBOAT5 membrane bound O-acyltransferase domain containing 5".

[UniProt-9] "UniProt, Q6P1A2". Pristupljeno 11. 8. 2021.

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