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MFN1

From Wikipedia, the free encyclopedia

MFN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMFN1, hfzo1, hfzo2, mitofusin 1
External IDsOMIM: 608506; MGI: 1914664; HomoloGene: 11481; GeneCards: MFN1; OMA:MFN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017927
NM_033540

NM_024200

RefSeq (protein)

NP_284941

NP_077162

Location (UCSC)Chr 3: 179.35 – 179.39 MbChr 3: 32.58 – 32.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.[5][6][7]

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171109Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027668Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434. S2CID 20528590.
  6. ^ Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. doi:10.1242/jcs.114.5.867. PMID 11181170.
  7. ^ a b "Entrez Gene: MFN1 mitofusin 1".

Further reading

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