Metiamid

Metiamid
	N-metil-N'-(2[(4-metil-1H-imidazol-5-il)metil]tio}etil)tioureja
Identifikacija
PubChem	1548992
ChemSpider	1265996
DrugBank	DB08805
ChEMBL	CHEMBL275446
Jmol-3D slike	Slika 1
SMILES
	S=C(NC)NCCSCc1ncnc1C
InChI
	InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14) ; Kod: FPBPLBWLMYGIQR-UHFFFAOYSA-N
Svojstva
Molekulska formula	C9H16N4S2
Molarna masa	244.38 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Metiamid je histaminski antagonist H₂-receptora koji je razvijen počevši od burimamida.^[5] On je bio prvo intermedijarno jedinjenje u razvoju uspešnog leka protiv čireva, cimetidina (Tagameta).^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. str. 204–206, 586-588. ISBN 0-19-850346-6.
↑ „Tagamet^®: Discovery of Histamine H₂-receptor Antagonists”. National Historic Chemical Landmarks. American Chemical Society. Arhivirano iz originala na datum 2012-12-09. Pristupljeno 25. 6. 2012.

Vanjske veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Clayden-5] Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. str. 204–206, 586-588. ISBN 0-19-850346-6.

[ACS_Landmarks-6] „Tagamet^®: Discovery of Histamine H₂-receptor Antagonists”. National Historic Chemical Landmarks. American Chemical Society. Arhivirano iz originala na datum 2012-12-09. Pristupljeno 25. 6. 2012.

[1]

[2]

[3]

[4]

[5]

[6]