PCYOX1

PCYOX1
Identifikatori
Aliasi	PCYOX1
Vanjski ID-jevi	OMIM: 610995 MGI: 1914131 HomoloGene: 9458 GeneCards: PCYOX1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	70,281,185 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	86,374,136 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor; • prenylcysteine oxidase activity;
Ćelijska komponenta	• ćelijska membrana; • Egzosom; • vacuolar membrane; • very-low-density lipoprotein particle; • Lizozom;
Biološki proces	• prenylcysteine metabolic process; • chloride transport; • chloride transmembrane transport; • prenylcysteine catabolic process; • prenylated protein catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	51449
	66881
	ENSG00000116005
	ENSMUSG00000029998
	Q9UHG3
	Q9CQF9
	NM_016297
	NM_025823; NM_001355687
	NP_057381
	NP_080099; NP_001342616
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

PCBP1 antisens RNK 1 jest protein koji je kod ljudi kodiran genom PCBP1-AS1 sa hromosoma 2.^[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 505 aminokiselina, a molekulska težina 56.640 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGRVVAELVS	SLLGLWLLLC	SCGCPEGAEL	RAPPDKIAII	GAGIGGTSAA
YYLRQKFGKD	VKIDLFEREE	VGGRLATMMV	QGQEYEAGGS	VIHPLNLHMK
RFVKDLGLSA	VQASGGLLGI	YNGETLVFEE	SNWFIINVIK	LVWRYGFQSL
RMHMWVEDVL	DKFMRIYRYQ	SHDYAFSSVE	KLLHALGGDD	FLGMLNRTLL
ETLQKAGFSE	KFLNEMIAPV	MRVNYGQSTD	INAFVGAVSL	SCSDSGLWAV
EGGNKLVCSG	LLQASKSNLI	SGSVMYIEEK	TKTKYTGNPT	KMYEVVYQIG
TETRSDFYDI	VLVATPLNRK	MSNITFLNFD	PPIEEFHQYY	QHIVTTLVKG
ELNTSIFSSR	PIDKFGLNTV	LTTDNSDLFI	NSIGIVPSVR	EKEDPEPSTD
GTYVWKIFSQ	ETLTKAQILK	LFLSYDYAVK	KPWLAYPHYK	PPEKCPSIIL
HDRLYYLNGI	ECAASAMEMS	AIAAHNAALL	AYHRWNGHTD	MIDQDGLYEK
LKTEL

Funkcija

U jednom istraživanju iz 2017. , identificirani su skupovi funkcionalno povezanih dugolančanih nekodirajućih RNK (lncRNA) i iRNK i procijenivan značaj lncRNK u mreži lncRNK-iRNK. Sroveli su ponderiranu analizu mreže koekspresije gena i analizu obogaćivanja da identifciraju funkcionalne module koekspresiranih lncRNK i iRNK u monojedarnim ćelijama periferne krvi 43 žene. Identificirali su sedam modula i pronašli lokus lncRNK u svakom modulu. Četiri od sedam modula imala su značajna obogaćenja genske ontologije. Neke od čvorišnih lncRNK (npr. SSX8, UCA1, HOXA-AS2, STARD4-AS1 i PCBP1-AS1) imaju poznate funkcije povezane s bolestima kao što su kanceri. U zaključku se navodi da su pokazali da lncRNK mogu imati važnu ulogu u modulima koekspresije lncRNK-iRNK.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116005 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029998 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PCBP1 antisense RNA 1". Pristupljeno 30. 7. 2018.
^ "UniProt, Q9UHG3" (jezik: engleski). Pristupljeno 14. 11. 2021.
^ Xing-Bo Mo, Long-Fei Wu, Xiao-Wei Zhu , Wei Xia , Lan Wang , Pei He, Peng-Fei Bing, Xin Lu, Yong-Hong Zhang , Fei-Yan Deng , Shu-Feng Lei (2017): Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells.Epigenomics, 9(7): 943-954; pmid: 28621149; doi: 10.2217/epi-2016-0178

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116005 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029998 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PCBP1 antisense RNA 1". Pristupljeno 30. 7. 2018.

[UniProt-6] "UniProt, Q9UHG3" (jezik: engleski). Pristupljeno 14. 11. 2021.

[7] Xing-Bo Mo, Long-Fei Wu, Xiao-Wei Zhu , Wei Xia , Lan Wang , Pei He, Peng-Fei Bing, Xin Lu, Yong-Hong Zhang , Fei-Yan Deng , Shu-Feng Lei (2017): Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells.Epigenomics, 9(7): 943-954; pmid: 28621149; doi: 10.2217/epi-2016-0178

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