PLP2

PLP2
Identifiers
Aliases	PLP2, A4, A4LSB, proteolipid protein 2 (colonic epithelium-enriched), proteolipid protein 2
External IDs	OMIM: 300112; MGI: 1298382; HomoloGene: 2003; GeneCards: PLP2; OMA:PLP2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.23 Start 49,171,898 bp End 49,175,235 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.1|X 3.45 cM Start 7,534,180 bp End 7,537,629 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of abdomen Descending thoracic aorta mucosa of esophagus skin of leg right coronary artery ascending aorta nipple popliteal artery tibial arteries Top expressed in granulocyte epidermis cornea corneal stroma lactiferous gland lip skin of back white adipose tissue yolk sac stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion transmembrane transporter activity protein binding chemokine binding Cellular component membrane endoplasmic reticulum membrane plasma membrane endoplasmic reticulum integral component of membrane Biological process cytokine-mediated signaling pathway chemotaxis ion transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5355 18824 Ensembl ENSG00000102007 ENSMUSG00000031146 UniProt Q04941 Q9R1Q7 RefSeq (mRNA) NM_002668 NM_019755 RefSeq (protein) NP_002659 NP_002659.1 NP_062729 Location (UCSC) Chr X: 49.17 – 49.18 Mb Chr X: 7.53 – 7.54 Mb PubMed search
Wikidata
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Proteolipid protein 2 is a protein that in humans is encoded by the PLP2 gene.

Further reading

• Breitwieser GE, McLenithan JC, Cortese JF, et al. (1997). "Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics". Am. J. Physiol. 272 (3 Pt 1): C957–65. doi:10.1152/ajpcell.1997.272.3.C957. PMID 9124532.
• Fisher SE, Ciccodicola A, Tanaka K, et al. (1998). "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp" (PDF). Genomics. 45 (2): 340–347. doi:10.1006/geno.1997.4941. hdl:11858/00-001M-0000-0012-CBE6-7. PMID 9344658.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang B, Nguyen M, Breckenridge DG, et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–14468. doi:10.1074/jbc.M209684200. PMID 12529377.
• Lee SM, Shin H, Jang SW, et al. (2004). "PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells". Biochem. Biophys. Res. Commun. 324 (2): 768–772. doi:10.1016/j.bbrc.2004.09.118. PMID 15474493.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–208. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
• Zhang L, Jie C, Obie C, et al. (2007). "X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation". Genome Res. 17 (5): 641–648. doi:10.1101/gr.5336307. PMC 1855181. PMID 17416750.
• Stirling PC, Srayko M, Takhar KS, et al. (2007). "Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression". Mol. Biol. Cell. 18 (6): 2336–2345. doi:10.1091/mbc.E07-01-0069. PMC 1877119. PMID 17429077.