Prostaglandin E1

Prostaglandin E1
(IUPAC) ime
	7-[(1R,3R)-3-hidroksi-2-[(1E,3S)-3-hidroksiokt-1-en-1-il]-5-oksociklopentil]heptanska kiselina
Klinički podaci
MedlinePlus	a695022
Identifikatori
CAS broj	745-65-3
ATC kod	C01EA01 G04BE01
PubChem	149351
DrugBank	DB00770
ChEMBL	CHEMBL495
Hemijski podaci
Formula	C20H34O5
Mol. masa	354,481 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/t15-,16+,17+,19+/m0/s1; Key: GMVPRGQOIOIIMI-DODZYUBVSA-N
Farmakoinformacioni podaci
Trudnoća	C(US)
Pravni status

Prostaglandin E₁ (PGE1, alprostadil^[4]) je prostaglandin. On je lek koji se koristi za tretman impontencije.^[5]. On isto tako ima vazodilataciona svojstva.

Medicinske upotrebe

Patent ductus arteriosus

Alprostadil se koristi za održavanje otvorenog arterijskog protoka kod novorođenčadi. To je prvenstveno korisno kad postoji opasnost od prevremenog zatvaranja arterijskog protoka kod novorođenčeta sa urođenim srčanim manama.

Seksualna disfunkcija

Alprostadil je u prodaji u Sjedinjenim Državama u obliku supozitorija mokraćne cevi i injekcija. Supositorije se prodaju pod imenom MUSE^[6] (engl. Medicated Urethral Suppository for Erection), dok su injekcije dostupne pod imenima Edeks^[7] i caverject.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Cawello W, Leonhardt A, Schweer H, Seyberth HW, Bonn R, Lomeli AL (September 1995). „Dose proportional pharmacokinetics of alprostadil (prostaglandin E1) in healthy volunteers following intravenous infusion”. British Journal of Clinical Pharmacology 40 (3): 273–6. PMC 1365109. PMID 8527291.
↑ Harding LM, Adeniyi A, Everson R, Barker S, Ralph DJ, Baranowski AP (December 2002). „Comparison of a needle-free high-pressure injection system with needle-tipped injection of intracavernosal alprostadil for erectile dysfunction”. International Journal of Impotence Research 14 (6): 498–501. DOI:10.1038/sj.ijir.3900916. PMID 12494285.
↑ MUSE
↑ Edex
↑ Caverject

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid8527291-4] Cawello W, Leonhardt A, Schweer H, Seyberth HW, Bonn R, Lomeli AL (September 1995). „Dose proportional pharmacokinetics of alprostadil (prostaglandin E1) in healthy volunteers following intravenous infusion”. British Journal of Clinical Pharmacology 40 (3): 273–6. PMC 1365109. PMID 8527291.

[pmid12494285-5] Harding LM, Adeniyi A, Everson R, Barker S, Ralph DJ, Baranowski AP (December 2002). „Comparison of a needle-free high-pressure injection system with needle-tipped injection of intracavernosal alprostadil for erectile dysfunction”. International Journal of Impotence Research 14 (6): 498–501. DOI:10.1038/sj.ijir.3900916. PMID 12494285.

[6] MUSE

[7] Edex

[8] Caverject

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