S Wikipedije, slobodne enciklopedije
Romboidno-vezani protein 2 jest protein koji je kod ljudi kodiran genom RHBDL2 sa hromosoma 1 .[ 5]
Dužina polipeptidnog lanca je 303 aminokiseline , a molekulska težina 34.021 Da .[ 6]
10 20 30 40 50 MAAVHDLEME SMNLNMGREM KEELEEEEKM REDGGGKDRA KSKKVHRIVS KWMLPEKSRG TYLERANCFP PPVFIISISL AELAVFIYYA VWKPQKQWIT LDTGILESPF IYSPEKREEA WRFISYMLVH AGVQHILGNL CMQLVLGIPL EMVHKGLRVG LVYLAGVIAG SLASSIFDPL RYLVGASGGV YALMGGYFMN VLVNFQEMIP AFGIFRLLII ILIIVLDMGF ALYRRFFVPE DGSPVSFAAH IAGGFAGMSI GYTVFSCFDK ALLKDPRFWI AIAAYLACVL FAVFFNIFLS PAN
Protein kodiran ovim genom je član porodice romboidne proteaze integralnih membranskih proteina . Ova porodica sadrži proteine koji su povezani sa drozofilsim rhomboid-1 . Članovi ove porodice se nalaze i kod prokariota i eukariota i smatra se da funkcionišu kao intramembranske serin-proteaze .
RHBDL2 funkcionira kao shedaza i na plazmamembrani .[ 7] supstrati RHBDL2 uključuju trombomodulin i epidermni faktor rasta ;[ 7] tpa I membranskog proteina , uključujući BCAM , SPINT1 i CLCP1 .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000158315 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043333 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)" .^ "UniProt, Q9NX52" (jezik: eng.). Pristupljeno 4. 12. 2021 .CS1 održavanje: nepoznati jezik (link ) ^ a b Lichtenthaler SF, Lemberg MK, Fluhrer R (august 2018). "Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments" . The EMBO Journal . 37 (15). doi :10.15252/embj.201899456 . PMC 6068445 PMID 29976761 . ^ Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K (august 2017). "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis" . Scientific Reports . 7 (1): 7283. doi :10.1038/s41598-017-07556-3 . PMC 5544772 PMID 28779096 .
Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M (maj 2011). "Mammalian EGF receptor activation by the rhomboid protease RHBDL2" . EMBO Reports . 12 (5): 421–7. doi :10.1038/embor.2011.50 . PMC 3090019 PMID 21494248 . Pascall JC, Brown KD (april 2004). "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2". Biochemical and Biophysical Research Communications . 317 (1): 244–52. doi :10.1016/j.bbrc.2004.03.039 . PMID 15047175 . Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, et al. (decembar 2011). "Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing" . The Journal of Investigative Dermatology . 131 (12): 2486–94. doi :10.1038/jid.2011.230 PMID 21833011 . Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, et al. (februar 2010). "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer" . Proceedings of the National Academy of Sciences of the United States of America . 107 (5): 2136–40. Bibcode :2010PNAS..107.2136X . doi :10.1073/pnas.0914061107 PMC 2836698 PMID 20080650 . Urban S, Freeman M (juni 2003). "Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain" . Molecular Cell . 11 (6): 1425–34. doi :10.1016/s1097-2765(03)00181-3 PMID 12820957 . Urban S, Lee JR, Freeman M (oktobar 2001). "Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases" . Cell . 107 (2): 173–82. doi :10.1016/s0092-8674(01)00525-6 PMID 11672525 . S2CID 9026083 . Lei X, Li YM (decembar 2009). "The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity". Journal of Molecular Biology . 394 (5): 815–25. doi :10.1016/j.jmb.2009.10.025 . PMID 19850051 .
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država , koji je u javnom vlasništvu .
