Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4gene.[5][6]
SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric length from the ALD gene. Although alternative splicing of exon 5 has not been detected in the human SSR4 gene, transcript variants missing the region homologous to the human exon 5 have been detected in both Xenopus laevis and Mus musculus.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID9286695.
Wang Z, VandeBerg JL (2005). "Cloning and molecular characterization of a human ortholog of Monodelphis TRAPD in ultraviolet B-induced melanoma". Melanoma Res. 14 (2): 107–14. doi:10.1097/00008390-200404000-00005. PMID15057039. S2CID12281868.
