TAS2R4
| Receptor ukusa tip 2 član 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R4; T2R4 | ||||||||||
| Vanjski ID | OMIM: 604869 MGI: 2681210 HomoloGene: 49480 IUPHAR: GeneCards: TAS2R4 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 50832 | 57253 | |||||||||
| Ensembl | ENSG00000127364 | ENSMUSG00000037140 | |||||||||
| UniProt | Q9NYW5 | Q9JKT3 | |||||||||
| RefSeq (mRNA) | NM_016944.1 | NM_020502.1 | |||||||||
| RefSeq (protein) | NP_058640.1 | NP_065248.1 | |||||||||
| Lokacija (UCSC) |
Chr 7: 141.48 - 141.48 Mb |
Chr 6: 40.44 - 40.44 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor ukusa tip 2 član 4 je protein koji je kod ljudi kodiran TAS2R4 genom.[1][2][3]
Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Ovaj receptor ukusa ne sadrži introne. Njegov gen se nalazi na hromozomu 7.[3]
Reference
[уреди | уреди извор]- ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). „A novel family of mammalian taste receptors”. Cell. 100 (6): 693—702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.
- ^ Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). „T2Rs function as bitter taste receptors”. Cell. 100 (6): 703—11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.
- ^ а б „Entrez Gene: TAS2R4 taste receptor, type 2, member 4”.
Literatura
[уреди | уреди извор]- Kinnamon SC (2000). „A plethora of taste receptors”. Neuron. 25 (3): 507—10. PMID 10774719. doi:10.1016/S0896-6273(00)81054-5.
- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Firestein S (2000). „The good taste of genomics”. Nature. 404 (6778): 552—3. PMID 10766221. doi:10.1038/35007167.
- Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse”. Nature. 404 (6778): 601—4. PMID 10766242. doi:10.1038/35007072.
- Ueda T; Ugawa S; Ishida Y; et al. (2001). „Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting”. Biochem. Biophys. Res. Commun. 285 (1): 147—51. PMID 11437385. doi:10.1006/bbrc.2001.5136.
- Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719
. PMID 15744053. doi:10.1534/genetics.104.037523.