TRIM28

Motivo tripartito 28
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1FP0 , 2RO1 , 2YVR
Identificadores
Símbolos	TRIM28 (HGNC: 16384) KAP1, FLJ29029, RNF96, TF1B, TIF1B
Identificadores; externos	OMIM: 601742 ; HomoloGene: 21175 ; EBI: TRIM28; GeneCards: Gen TRIM28; UniProt: TRIM28;
Locus	Cr. 19 q13.43
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
10155	21849
Véase HS	Véase MM
Q13263	Q62318
NM_005762	NM_011588
NP_005753	NP_035718
Cr. 19:; 59.06 – 59.06 Mb	Cr. 7:; 13.02 – 13.03 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

Motivo tripartito 28 (TRIM28), también conocida como factor intermediario transcripcional 1β (TIF1β), es una proteína codificada en humanos por el gen trim28.^[1]^[2]

Función

TRIM28 está implicado en el control transcripcional por interacción con el dominio de represión asociado a la caja Krüppel presente en multitud de factores de transcripción. La proteína se localiza en el núcleo celular y parece encontrarse asociada con regiones específicas de la cromatina. Esta proteína pertenece a la familia de motivos tripartitos. Este motivo tripartito incluye tres dominios de unión a zinc, un dominio de dedos RING, una B-box tipo 1, una B-box tipo 2 y una región de hélice superenrollada.^[3]

Interacciones

La proteína TRIM28 ha demostrado ser capaz de interaccionar con:

Véase también

Corregulador transcripcional

Referencias

↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (mayo de 2001). «The tripartite motif family identifies cell compartments». Embo J. 20 (9): 2140-51. PMC 125245. PMID 11331580. doi:10.1093/emboj/20.9.2140.
↑ Capili AD, Schultz DC, RauscherIII FJ, Borden KL (enero de 2001). «Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains». Embo J. 20 (1-2): 165-77. PMC 140198. PMID 11226167. doi:10.1093/emboj/20.1.165.
↑ «Entrez Gene: TRIM28 tripartite motif-containing 28».
↑ Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. de 2002). «Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha». EMBO J. (England) 21 (21): 5797-806. ISSN 0261-4189. PMID 12411497.
↑ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. de 2002). «Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction». J. Cell. Sci. (England) 115 (Pt 17): 3439-48. ISSN 0021-9533. PMID 12154074.
↑ Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. de 2001). «Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins». Mol. Cell (United States) 7 (4): 729-39. ISSN 1097-2765. PMID 11336697.
↑ Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. de 2000). «Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential». Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449-65. ISSN 0270-7306. PMID 10938122.
↑ Moosmann, P; Georgiev O, Le Douarin B, Bourquin J P, Schaffner W (Dec. de 1996). «Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1». Nucleic Acids Res. (ENGLAND) 24 (24): 4859-67. ISSN 0305-1048. PMID 9016654.
↑ Peng, H; Begg G E, Harper S L, Friedman J R, Speicher D W, Rauscher F J (Jun. de 2000). «Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain». J. Biol. Chem. (UNITED STATES) 275 (24): 18000-10. ISSN 0021-9258. PMID 10748030. doi:10.1074/jbc.M001499200.
↑ Rooney, J W; Calame K L (Nov. de 2001). «TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937». Genes Dev. (United States) 15 (22): 3023-38. ISSN 0890-9369. PMID 12269264. doi:10.1101/gad.937201.
↑ ^a ^b Chang, C J; Chen Y L, Lee S C (Oct. de 1998). «Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression». Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880-7. ISSN 0270-7306. PMID 9742105.
↑ Schultz, David C; Ayyanathan Kasirajan, Negorev Dmitri, Maul Gerd G, Rauscher Frank J (Apr. de 2002). «SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins». Genes Dev. (United States) 16 (8): 919-32. ISSN 0890-9369. PMID 11959841. doi:10.1101/gad.973302.

Enlaces externos

MeSH: TRIM28 protein, human (en inglés)

Datos: Q18035077

[pmid11331580-1] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (mayo de 2001). «The tripartite motif family identifies cell compartments». Embo J. 20 (9): 2140-51. PMC 125245. PMID 11331580. doi:10.1093/emboj/20.9.2140.

[pmid11226167-2] Capili AD, Schultz DC, RauscherIII FJ, Borden KL (enero de 2001). «Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains». Embo J. 20 (1-2): 165-77. PMC 140198. PMID 11226167. doi:10.1093/emboj/20.1.165.

[entrez-3] «Entrez Gene: TRIM28 tripartite motif-containing 28».

[pmid12411497-4] Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. de 2002). «Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha». EMBO J. (England) 21 (21): 5797-806. ISSN 0261-4189. PMID 12411497.

[pmid12154074-5] Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. de 2002). «Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction». J. Cell. Sci. (England) 115 (Pt 17): 3439-48. ISSN 0021-9533. PMID 12154074.

[pmid11336697-6] Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. de 2001). «Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins». Mol. Cell (United States) 7 (4): 729-39. ISSN 1097-2765. PMID 11336697.

[pmid10938122-7] Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. de 2000). «Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential». Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449-65. ISSN 0270-7306. PMID 10938122.

[pmid9016654-8] Moosmann, P; Georgiev O, Le Douarin B, Bourquin J P, Schaffner W (Dec. de 1996). «Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1». Nucleic Acids Res. (ENGLAND) 24 (24): 4859-67. ISSN 0305-1048. PMID 9016654.

[pmid10748030-9] Peng, H; Begg G E, Harper S L, Friedman J R, Speicher D W, Rauscher F J (Jun. de 2000). «Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain». J. Biol. Chem. (UNITED STATES) 275 (24): 18000-10. ISSN 0021-9258. PMID 10748030. doi:10.1074/jbc.M001499200.

[pmid11711437-10] Rooney, J W; Calame K L (Nov. de 2001). «TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937». Genes Dev. (United States) 15 (22): 3023-38. ISSN 0890-9369. PMID 12269264. doi:10.1101/gad.937201.

[pmid9742105-11] Chang, C J; Chen Y L, Lee S C (Oct. de 1998). «Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression». Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880-7. ISSN 0270-7306. PMID 9742105.

[pmid11959841-12] Schultz, David C; Ayyanathan Kasirajan, Negorev Dmitri, Maul Gerd G, Rauscher Frank J (Apr. de 2002). «SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins». Genes Dev. (United States) 16 (8): 919-32. ISSN 0890-9369. PMID 11959841. doi:10.1101/gad.973302.

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