| County
|
Location
|
#
|
Destinations
|
Notes
|
| Spartanburg
|
|
1
|
 SC 14 – Landrum
|
|
|
|
5
|
 SC 11 – Campobello, Chesnee
|
|
|
|
10
|
 SC 292 – Inman
|
|
|
|
15
|
 US 176 – Inman, Spartanburg
|
|
|
|
16
|
John Dodd Road - Wellford
|
|
|
|
17
|
New Cut Road - Sigsbee
|
|
|
|
18
|
 I-85 – Greenville, Charlotte
|
Signed as exits 18A (south) and 18B (north)
|
|
|
19
|
 I-85 BL – Spartanburg
|
Signed as exits 19A (south) and 19B (north)
|
|
|
21
|
 US 29 – Greer, Spartanburg
|
Signed as exits 21A (south) and 21B (north)
|
|
|
22
|
 SC 296 (Reidville Road) – Roebuck, Spartanburg
|
|
|
|
28
|
 US 221 – Spartanburg, Moore, Woodruff
|
|
|
|
35
|
Road 50 - Woodruff
|
|
|
|
38
|
 SC 146 – Cross Anchor, Woodruff
|
|
|
|
41
|
 SC 92 – Enoree
|
|
|
|
44
|
 SC 49 – Laurens, Cross Anchor, Union
|
|
| Bridge over the Enoree River
|
| Laurens
|
|
|
51
|
 I-385 – Laurens, Greenville
|
Westbound exit and eastbound entrance
|
|
|
52
|
 SC 56 – Cross Anchor, Clinton
|
|
|
|
54
|
 SC 72 – Clinton, Whitmire
|
|
|
|
60
|
 SC 66 – Joanna, Whitmire
|
|
| Newberry
|
|
66
|
Road 32 - Jalapa
|
|
|
|
72
|
 SC 121 – Newberry, Whitmire, Union
|
|
|
|
74
|
 SC 34 – Newberry, Winnsboro
|
|
|
|
76
|
 SC 219 – Newberry, Pomaria
|
|
|
|
82
|
 SC 773 – Prosperity, Pomaria
|
|
|
|
85
|
 SC 202 – Pomaria, Little Mountain
|
|
| Lexington
|
|
91
|
Columbia Avenue - Chapin
|
|
| Richland
|
|
97
|
US 176 – Ballentine, White Rock, Peak
|
|
| Irmo
|
101
|
 US 76 west / US 176 (Broad River Road) – Ballentine, White Rock
|
West end of US 76 overlap; signed as exits 101A (west) and 101B (east)
|
| 102
|
 SC 60 (Lake Murray Boulevard) – Irmo
|
Signed as exits 102A (west) and 102B (east)
|
|
|
103
|
Harbison Boulevard
|
Exit to reach the Columbiana Mall.
|
| Lexington
|
|
104
|
Piney Grove Road
|
|
|
|
106
|
St. Andrews Road
|
Signed as exits 106A (west) and 106B (east-along with Fernandina Road and Burning Tree Road) westbound.
|
| Richland
|
|
107
|
 I-20 - Augusta, Florence
|
Signed as exits 107A (west) and 107B (east)
|
| Columbia
|
108A
|
Bush River Road
|
|
| 108B
|
 I-126 (US 76 east) – Downtown Columbia
|
East end of US 76 overlap
|
| Bridge over the Saluda River
|
| Lexington
|
|
|
110
|
 US 378 – Lexington, West Columbia
|
|
|
|
111
|
 US 1 – Lexington, West Columbia
|
Signed as exits 111A (south) and 111B (north)
|
| Springdale
|
113
|
 SC 302 – Columbia Airport, Cayce
|
|
| Cayce
|
115
|
  US 21 / US 176 / US 321 – Gaston, Cayce, Columbia
|
|
| 116
|
 I-77 north - Charlotte
|
|
|
|
119
|
US 21 / US 176 – St. Matthews, Dixiana
|
|
| Calhoun
|
|
125
|
Old Sandy Run Road (Road 31) - Gaston
|
Exit to reach Sandy Run.
|
| Lexington
|
|
129
|
US 21
|
|
| Calhoun
|
|
136
|
 SC 6 – North, St. Matthews, Swansea
|
|
| Orangeburg
|
|
139
|
Burke Road - St. Matthews
|
|
|
|
145
|
 US 601 – Orangeburg, St. Matthews
|
Signed as exits 145A (south) and 145B (north)
|
|
|
154
|
 US 301 – Orangeburg, Santee, Elloree
|
Signed as exits 154A (south) and 154B (north)
|
US 19 / US 23 / US 74 west – Clyde, Waynesville, Maggie Valley, Franklin, Murphy, Atlanta
NC 215 – Canton
I-26 east – Hendersonville, Spartanburg, Asheville Airport
I-26 west / I-240 – Asheville
NC 191 / Blue Ridge Parkway
NC 146 – Skyland
NC 280 – Asheville Regional Airport, Arden
US 64 – Hendersonville, Bat Cave
US 25 south to US 176 / NC 225 - Greenville
US 74 east / NC 108 – Columbus, Rutherfordton, Tryon