Galaninski receptor 2
| edit |
| Galaninski receptor 2 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | GALR2; GALNR2; MGC125983; MGC125984 | ||
| Vanjski ID | OMIM: 603691 MGI: 1337018 HomoloGene: 2863 IUPHAR: GAL2 GeneCards: GALR2 Gene | ||
| Pregled RNK izražavanja | |||
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| podaci | |||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 8811 | 14428 | |
| Ensembl | ENSG00000182687 | ENSMUSG00000020793 | |
| UniProt | O43603 | Q14A53 | |
| RefSeq (mRNA) | NM_003857 | NM_010254 | |
| RefSeq (protein) | NP_003848 | NP_034384 | |
| Lokacija (UCSC) | Chr 17: 71.58 - 71.59 Mb | Chr 11: 116.1 - 116.1 Mb | |
| PubMed pretraga | [1] | [2] | |
Galaninski receptor 2, (GAL2) je G protein spregnuti receptor kodiran GALR2 genom.[1]
Galanin je važan neuromodulator prisutan u mozgu, gastrointestinalnom sistemu, i hipotalamo-hipofiznoj osi. To je peptid sa 30 aminokiselina koji nije C-terminalno amidiran. On potentno stimuliše sekreciju hormona rasta, usporava brzinu srca, ukida sinusnu aritmiju, i inhibira gastrointestinalni motilitet nakon obroka. Dejstvo galanina je posredovano kroz interakciju sa specifičnim membranskim receptorima koji su članovi 7-transmembranske familije G protein-spregnutih receptora. GALR2 interaguje sa N-terminalnim ostacima galanina. Primarni signalni mehanizam GALR2 receptora je put fosfolipaze C/protein kinaze C (preko Gq), u kontrastu sa GALR1, koji prenosi svoj signal inhibicijom adenilat ciklaze kroz Gi. Bilo je pokazano da se GALR2 efektivno spreže sa Gq i Gi proteinima, i da može da simultano aktivira dva nezavisna puta prenosa signala.[1]
- Bloomquist BT, Beauchamp MR, Zhelnin L, et al. (1998). „Cloning and expression of the human galanin receptor GalR2.”. Biochem. Biophys. Res. Commun. 243 (2): 474–9. DOI:10.1006/bbrc.1998.8133. PMID 9480833.
- Fathi Z, Battaglino PM, Iben LG, et al. (1998). „Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.”. Brain Res. Mol. Brain Res. 58 (1-2): 156–69. DOI:10.1016/S0169-328X(98)00116-8. PMID 9685625.
- Kolakowski LF, O'Neill GP, Howard AD, et al. (1998). „Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.”. J. Neurochem. 71 (6): 2239–51. DOI:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121.
- Borowsky B, Walker MW, Huang LY, et al. (1999). „Cloning and characterization of the human galanin GALR2 receptor.”. Peptides 19 (10): 1771–81. DOI:10.1016/S0196-9781(98)00133-8. PMID 9880084.
- Berger A, Tuechler C, Almer D, et al. (2002). „Elevated expression of galanin receptors in childhood neuroblastic tumors.”. Neuroendocrinology 75 (2): 130–8. DOI:10.1159/000048229. PMID 11867941.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Berger A, Lang R, Moritz K, et al. (2004). „Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells.”. Endocrinology 145 (2): 500–7. DOI:10.1210/en.2003-0649. PMID 14592962.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Belfer I, Hipp H, Bollettino A, et al. (2007). „Alcoholism is associated with GALR3 but not two other galanin receptor genes.”. Genes, Brain and Behavior 6 (5): 473–81. DOI:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.
- „Galanin Receptors: GAL2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.