NR2F1

COUP-TF1 (COUP transkripcijski faktor 1) znan i kao NR2F1 (od eng. skr. za Nuclear Receptor subfamily 2, član 1) grupe F, jest protein koji je kod ljudi kodiran genom NR2F1 sa hromosoma 5.^[1]^[2] Ovaj protein je član receptoa jedarnih hormona iz porodice receptora steroidnih hormona.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 423 aminokiseline, а molekulska težina 46.156 Da.^[3]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAMVVSSWRD	PQDDVAGGNP	GGPNPAAQAA	RGGGGGAGEQ	QQQAGSGAPH
TPQTPGQPGA	PATPGTAGDK	GQGPPGSGQS	QQHIECVVCG	DKSSGKHYGQ
FTCEGCKSFF	KRSVRRNLTY	TCRANRNCPI	DQHHRNQCQY	CRLKKCLKVG
MRREAVQRGR	MPPTQPNPGQ	YALTNGDPLN	GHCYLSGYIS	LLLRAEPYPT
SRYGSQCMQP	NNIMGIENIC	ELAARLLFSA	VEWARNIPFF	PDLQITDQVS
LLRLTWSELF	VLNAAQCSMP	LHVAPLLAAA	GLHASPMSAD	RVVAFMDHIR
IFQEQVEKLK	ALHVDSAEYS	CLKAIVLFTS	DACGLSDAAH	IESLQEKSQC
ALEEYVRSQY	PNQPSRFGKL	LLRLPSLRTV	SSSVIEQLFF	VRLVGKTPIE
TLIRDMLLSG	SSFNWPYMSI	QCS

Funkcija

COUP (kokošiji ovalbuminski uzvodni promotor) faktor transkripcije veže se za ovalbuminski promotor i, zajedno sa drugim proteinom (S300-II), stimulira [ početak transkripcije.^[4]^[5] COUP-TF1 veže se za direktna ponavljanja i palindromskom motivu 5'-AGGTCA-3 '.^[6]

Interakcije

Pokazalo se da COUP-TFI stupa u interakcije sa:

Klinički značaj

Mutacije u ovom genu povezane su sa Bosch-Boonstra-Schaafovim sindrom optičke atrofije.^[10]

Reference

^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
^ "UniProt, P10589" (jezik: engleski). Pristupljeno 18. 10. 2021.
^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986). "Identification of two factors required for transcription of the ovalbumin gene". Molecular and Cellular Biology. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.
^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. S2CID 25136877.
^ Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138.
^ ^a ^b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (maj 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
^ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62

Dopunska literatura

Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (Feb 1992). "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1448–52. Bibcode:1992PNAS...89.1448K. doi:10.1073/pnas.89.4.1448. PMC 48468. PMID 1311101.
Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.
Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW (Sep 1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)". The Journal of Biological Chemistry. 267 (25): 17617–23. doi:10.1016/S0021-9258(19)37087-5. PMID 1517211.
Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid receptor superfamily". Nature. 340 (6229): 163–6. Bibcode:1989Natur.340..163W. doi:10.1038/340163a0. PMID 2739739. S2CID 4364164.
Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (Dec 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Research. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047.
Sawaya BE, Rohr O, Aunis D, Schaeffer E (Sep 1996). "Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells". The Journal of Biological Chemistry. 271 (38): 23572–6. doi:10.1074/jbc.271.38.23572. PMID 8798567.
Rohr O, Aunis D, Schaeffer E (Dec 1997). "COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells". The Journal of Biological Chemistry. 272 (49): 31149–55. doi:10.1074/jbc.272.49.31149. PMID 9388268.
Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (maj 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
Klinge CM, Kaur K, Swanson HI (Jan 2000). "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of Biochemistry and Biophysics. 373 (1): 163–74. doi:10.1006/abbi.1999.1552. PMID 10620335.
Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E (Jan 2000). "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells". The Journal of Biological Chemistry. 275 (4): 2654–60. doi:10.1074/jbc.275.4.2654. PMID 10644726.
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene". The Journal of Biological Chemistry. 275 (5): 3446–54. doi:10.1074/jbc.275.5.3446. PMID 10652338.
Vlahou A, Flytzanis CN (Feb 2000). "Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle". Developmental Biology. 218 (2): 284–98. doi:10.1006/dbio.1999.9456. PMID 10656770.
Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
Gay F, Anglade I, Gong Z, Salbert G (Oct 2000). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Molecular Endocrinology. 14 (10): 1627–48. doi:10.1210/me.14.10.1627. PMID 11043578.
You M, Fischer M, Cho WK, Crabb D (Feb 2002). "Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors". Archives of Biochemistry and Biophysics. 398 (1): 79–86. doi:10.1006/abbi.2001.2713. PMID 11811951.
Lin F, Kolluri SK, Chen GQ, Zhang XK (Jun 2002). "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor". The Journal of Biological Chemistry. 277 (24): 21414–22. doi:10.1074/jbc.M201885200. PMID 11934895.
Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
Yu X, Mertz JE (Feb 2003). "Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1". Journal of Virology. 77 (4): 2489–99. doi:10.1128/JVI.77.4.2489-2499.2003. PMC 141100. PMID 12551987.

Vanjski linkovi

Lokacija ljudskog genoma NR2F1 i stranica sa detaljima o genu NR2F1 u UCSC Genome Browseru.
Lokacija ljudskog genoma NR2F2 i stranica sa detaljima o genu NR2F2 u UCSC Genome Browseru.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[entrez-1] "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".

[pmid8530078-2] Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.

[UniProt-3] "UniProt, P10589" (jezik: engleski). Pristupljeno 18. 10. 2021.

[pmid3796602-4] Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986). "Identification of two factors required for transcription of the ovalbumin gene". Molecular and Cellular Biology. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.

[pmid3040258-5] Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. S2CID 25136877.

[pmid9101138-6] Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138.

[pmid10744719-7] Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.

[pmid10207062-8] Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (maj 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.

[pmid12093745-9] Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.

[Hobbs2020-10] Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62

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