Nabitan

Nabitan
(IUPAC) ime
	(–)-8-(1,2-Dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl) -2H-(1)benzopyrano(4,3-c)pyridin-10-yl 1-piperidinebutyrate
Klinički podaci
Identifikatori
CAS broj	66556-74-9
ATC kod	nije dodeljen
PubChem	39503
ChemSpider	36117
Hemijski podaci
Formula	C35H52N2O3
Mol. masa	548.799 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C35H52N2O3/c1-7-9-11-15-26(3)27(4)28-23-31(39-33(38)16-14-21-36-19-12-10-13-20-36)34-29-25-37(18-8-2)22-17-30(29)35(5,6)40-32(34)24-28/h2,23-24,26-27H,7,9-22,25H2,1,3-6H3 ; Key: MCVPMHDADNVRKF-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Nabitan (Nabutam, Benzopiranoperidin, SP-106, Abbott 40656) je sintetički kanabinoidni analog dronabinola (Marinola).^[4] On manifestuje antiemetska i analgetička dejstva, verovatno putem vezivanja i aktiviranja CB₁ i CB₂ kanabinoidnih receptora. U testovima na životinjama je utvrđeno da redukuje intraokularni pritisak, te potencijalno može da nađe primenu u lečenju glaukoma.^[5]

Prednost nabitana u odnosu na druge kanabinoidne derivate je njegova rastvorljivost u vodi. Mogućnost njegove primene kao analgetik ili sedativ je izučavana,^[6] mada on nije dospeo do klinike. Jedan od razloga je da su dronabinol i nabilon korisniji. Nabita se ponekad koristi u istraživanjima potencijalne terapeutske primene kanabinoida.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Razdan RK. The Total Synthesis of Cannabinoids. Wiley-Interscience 1980
↑ Razdan RK, Howes JF. "Drugs related to tetrahydrocannabinol." Medicinal Research Reviews 1983; 3(2):119-146. PMID 6134882
↑ Archer RA. "The cannabinoids: therapeutic potentials." Annual Reports in Medicinal Chemistry 1974; 9: 253-259. PMID 12307093

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Razdan RK. The Total Synthesis of Cannabinoids. Wiley-Interscience 1980

[5] Razdan RK, Howes JF. "Drugs related to tetrahydrocannabinol." Medicinal Research Reviews 1983; 3(2):119-146. PMID 6134882

[6] Archer RA. "The cannabinoids: therapeutic potentials." Annual Reports in Medicinal Chemistry 1974; 9: 253-259. PMID 12307093

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