Normetanefrina
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| Normetanefrina | |
|---|---|
 | |
| Nome IUPAC | |
| 4-(2-amino-1-idrossi-etile)- 2-metossi-fenolo | |
| Caratteristiche generali | |
| Formula bruta o molecolare | C9H13NO3 |
| Massa molecolare (u) | 183.204 |
| Numero CAS | |
| PubChem | 1237 |
| SMILES | COC1=C(C=CC(=C1)C(CN)O)O |
| Indicazioni di sicurezza | |
La normetanefrina 4-(2-amino-1-idrossi-etile)- 2-metossi-fenolo è un metabolita intermedio del metabolismo delle catecolamine, si viene a formare in seguito all'azione dell'enzima catecol-O-metilasi sulla noradrenalina[1].
Sia la normetanefrina che la metanefrina vengono espulse nelle urine ed il loro dosaggio le rende un marcatore per i tumori secernenti catecolamine, come il feocromocitoma. Assieme alla metanefrina rappresenta il 20-40% dei cataboliti urinari provenienti dal metabolismo delle catecolamine[2].
Marcatore tumorale
[modifica | modifica wikitesto]I valori normali di metanefrina e normetanefrina, prendendo a riferimento le urine delle 24h sono compresi fra i 310-510 µg/24, un loro innalzamento viene associato all'insorgenza di feocromocitomi, sono possibili falsi positivi in quanto i valori di tali molecole nel sangue possono innalzarsi anche a seguito di terapie con IMAO, catecolamine, L-Dopa, beta-bloccanti e nei soggetti affetti da etilismo cronico.
Note
[modifica | modifica wikitesto]- ^ D. Andreani,G. Menzinger, D. Andreani; (1984) "Trattato di diagnostica funzionale endocrinologica" ISBN 88-299-0196-2
- ^ M. Mannelli1, T. Ercolino1, L. Becherini1, G. Bernini2, L. Simi1, G. Parenti1; Ligand Assay (2006); "Diagnosi genetica e biochimica del ferocromocitoma"
Bibliografia
[modifica | modifica wikitesto]- Anton AH, Sayre DF. J Pharmacol Exp Ther. 1966 Jul;153(1):15-29. Distribution of metanephrine and normetanephrine in various animals and their analysis in diverse biologic material. PMID 5921354
- Sato T, Yoshinaga K. Tohoku J Exp Med. 1973 Jul;110(3):283-7. A metanephrine test for a screening of catecholamine-producing tumors. PMID 4757670
- Eisenhofer G, Lenders JW. Adv Pharmacol. 1998;42:374-7. Clues to the diagnosis of pheochromocytoma from the differential tissue metabolism of catecholamines. PMID 9327920
- Shimbo S. Naika Hokan. 1968 Sep;15(9):299-310. Japanese. Clinical studies on urinary metanephrine and normetanephrine in various endocrine diseases. 2. Clinical studies on urinary metanephrine and normetanephrine in patients with pheochromyocytoma and a patient with neuroblastoma. PMID 5752086
- Wolf RL, Gherman CE, Lauer JD, Fish HL, Levey BR. Clin Sci Mol Med Suppl. 1973 Aug;45 Suppl 1:263s-7. A new urinary assay for separate normetanephrine and metanephrine with application for the diagnosis of phaeochromocytoma. PMID 4522173
- Griffin A, O'Shea P, FitzGerald R, O'Connor G, Tormey W. Ann Clin Biochem. 2011 Jan;48(Pt 1):41-4. Epub 2010 Dec 1. Establishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines. PMID 21123298
- Iwaoka T, Umeda T, Sato T. Nippon Rinsho. 1989 Dec;48 Suppl:1186-9. Japanese. Clinical significance of metanephrine and normetanephrine analysis in endocrine tests of the adrenal medulla and sympathetic nervous system. PMID 2621844
- Käser H, Türler K, Burri PH. Schweiz Med Wochenschr. 1971 Apr 3;101(13):484-7. German. Catecholamine metabolism in the tissue of malignant and benign tumors of the sympathetic nervous system. PMID 5558918
- Murakami M, Tomita K. Nippon Rinsho. 1999 Dec;57 Suppl:219-22. Review. Japanese. Metanephrine (M) and normetanephrine (NM). PMID 10778105
- Bertani LM, Dziedzic SW, Clarke DD, Gitlow SE. Clin Chim Acta. 1970 Nov;30(2):227-33. A gas-liquid chromatographic method for the separation and quantitation of normetanephrine and metanephrine in human urine. PMID 5478310
- Yaworsky DC, Wu AH, Hill DW. Clin Chim Acta. 2005 Mar;353(1-2):31-44. The use of plasma metanephrine to normetanephrine ratio to determine epinephrine poisoning. PMID 15698588
- Eisenhofer G, Lenders JW, Goldstein DS, Mannelli M, Csako G, Walther MM, Brouwers FM, Pacak K. Clin Chem. 2005 Apr;51(4):735-44. Epub 2005 Feb 17. Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines. PMID 15718487
- Lando LI, Krupenina LB, Aziavchik AV. Vopr Med Khim. 1973 Sep-Oct;19(5):501-5. Russian. Adrenaline and noradrenaline concentrations in rat tissues in different phases of single and repeated electroconvulsive seizures. PMID 4788174
- Raum WJ. Methods Enzymol. 1987;142:550-71. Enzymatic radioimmunoassay of epinephrine, norepinephrine, metanephrine, and normetanephrine. PMID 3600381
- Steinberg AB. Biol Psychol. 1974;2(2):135-49. Individual patterns of excretion of metanephrine and normetanephrine by children. PMID 4475599
- Bigelow LB, Dairman W, Weil-Malherbe H, Udenfriend S. Mol Pharmacol. 1969 Nov;5(6):565-71. Increased synthesis of catecholamines and their metabolites following the administration of phenoxybenzamine. PMID 5373892
- Canfell C, Binder SR, Khayam-Bashi H. Clin Chem. 1982 Jan;28(1):25-8. Quantitation of urinary normetanephrine and metanephrine by reversed-phase extraction and mass-fragmentographic analysis. PMID 7055927
- Iwata H, Fujimoto S, Nishikawa T, Hano K. Experientia. 1968 Apr 15;24(4):378-80. German. Pharmacologic studies in thiamine deficiency. I. Changes in the catecholamine content of tissues. PMID 5705198
- Miyoshi T, Tomita K.Nippon Rinsho. 2005 Aug;63 Suppl 8:395-8. Review. Japanese. Metanephrine (M), normetanephrine (NM) and fractionated metanephrines PMID 16149538
