Tamsulosin

Tamsulosin
(IUPAC) ime
	(R)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-; 2-methoxybenzenesulfonamide
Klinički podaci
Identifikatori
CAS broj	106133-20-4
ATC kod	G04CA02
PubChem	129211
DrugBank	APRD00036
ChemSpider	114457
UNII	G3P28OML5I
KEGG	D08560
ChEMBL	CHEMBL836
Hemijski podaci
Formula	C20H28N2O5S
Mol. masa	408.51
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 ; Key: DRHKJLXJIQTDTD-OAHLLOKOSA-N
Farmakokinetički podaci
Bioraspoloživost	100% (oralno)
Metabolizam	hepatički
Poluvreme eliminacije	9–13 sata
Izlučivanje	76% renalno
Farmakoinformacioni podaci
Licenca	US FDA:link
Trudnoća	B2(AU) B(US)
Pravni status	Samo na recept (S4) (AU) POM (UK) ℞-only (SAD)
Način primene	oralno

Tamsulosin (INN) je α_1a-selektivni alfa blokator koji se koristi u lečenju benignog uvećanja prostate (BPH). Tamsulosin je razvila kompanija Yamanouchi Pharmaceuticals (koja je sad deo Astellas Pharma), i u prodaji je od strane više kompanija pod licencom. Tamsulosin hidrohlorid kapsule sa produženim oslobađanjem su u prodaji pod imenima Flomaks, Flomakstra, Contiflo XL, i Urimaks, mada su generičke kapsule sa nepromenjenim trajanjem oslobađanja još uvek odobrene u mnogim zemljama. FDA je odobrila generički flomaks marta 2010.^[6]

Mehanizam

Glavni članak: Alfa blokator

Tamsulosin je selektivni antagonist α₁ receptor koji preferentno deluje na α_1A receptor prostate umesto α_1B receptora krvnih sudova.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ "FDA Approves First Generic Tamsulosin to Treat Enlarged Prostate Gland" (Press release). U.S. Food and Drug Administration (FDA). 2010-03-02.
↑ Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. str. 13. ISBN 1-59541-101-1.

Literatura

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] "FDA Approves First Generic Tamsulosin to Treat Enlarged Prostate Gland" (Press release). U.S. Food and Drug Administration (FDA). 2010-03-02.

[pharmnemonics-7] Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. str. 13. ISBN 1-59541-101-1.

[1]

[2]

[3]

[4]

[5]

[6]

[7]