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YTHDC2

S Wikipedije, slobodne enciklopedije
YTHDC2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2YU6

Identifikatori
AliasiYTHDC2
Vanjski ID-jeviOMIM: 616530 MGI: 2448561 HomoloGene: 11265 GeneCards: YTHDC2
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za YTHDC2
Genomska lokacija za YTHDC2
Bend5q22.2Početak113,513,694 bp[1]
Kraj113,595,285 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za YTHDC2
Genomska lokacija za YTHDC2
Bend18|18 B3Početak44,960,813 bp[2]
Kraj45,022,791 bp[2]
Ontologija gena
Molekularna funkcija nucleotide binding
GO:0001948, GO:0016582 vezivanje za proteine
RNA polymerase binding
ATP binding
hydrolase activity
GO:0008026 helicase activity
nucleic acid binding
ATP-dependent activity, acting on RNA
vezivanje sa RNK
N6-methyladenosine-containing RNA binding
GO:0034459 3'-5' RNA helicase activity
Ćelijska komponenta Endoplazmatski retikulum
citoplazma
jedro
ribonucleoprotein granule
Biološki proces response to tumor necrosis factor
GO:0033168, GO:0036404, GO:1902360 RNA processing
response to interleukin-1
positive regulation by host of viral genome replication
Spermatogeneza
spermatid development
Ćelijska diferencijacija
Ovogeneza
oocyte development
GO:0007126 Mejoza
germline cell cycle switching, mitotic to meiotic cell cycle
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_022828
NM_001345975
NM_001345976

NM_001163013

RefSeq (bjelančevina)

NP_001332904
NP_001332905
NP_073739

NP_001156485

Lokacija (UCSC)Chr 5: 113.51 – 113.6 MbChr 18: 44.96 – 45.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 2 sa YTH domenom je protein koji je kod ljudi kodiran genom YTHDC2.[5]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.430 aminokiselina, a molekulska težina 160.248 Da.[6]

1020304050
MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVN
IALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYL
TVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTER
GNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQE
EIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRR
LAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL
MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAA
LDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKE
KQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVF
SQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVD
YRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHF
GQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFD
DEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFA
DSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDV
VFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFR
LFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEP
PPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVV
LKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMAL
LRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV
RARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKK
VRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIR
CCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTA
NLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDE
ATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRK
SSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQ
SSLKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRN
LEISQQKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRMSS
EIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQIS
RDGQELEPLVGEQLLQLWERLPLGEKNTTD

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047188 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034653 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: YTH domain containing 2".
  6. ^ "UniProt, Q9H6S0" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura

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