ICI-199,441
Izgled
(IUPAC) ime | |||
---|---|---|---|
2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 115199-84-3 | ||
ATC kod | ? | ||
PubChem[1][2] | 3082718 | ||
Hemijski podaci | |||
Formula | C21H24Cl2N2O | ||
Mol. masa | 391.333 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
ICI-199,441 je lek, koji je visoko selektivni κ-opioidni agonist.[3] Postoji mogućnost da će on možda naći primenu u lečenju hroničnog bola.[4]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Costello GF, Main BG, Barlow JJ, Carroll JA, Shaw JS (July 1988). „A novel series of potent and selective agonists at the opioid kappa-receptor”. European Journal of Pharmacology 151 (3): 475–8. PMID 2850924.
- ↑ Narita M, Kaneko C, Miyoshi K, Nagumo Y, Kuzumaki N, Nakajima M, Nanjo K, Matsuzawa K, Yamazaki M, Suzuki T (April 2006). „Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 31 (4): 739–50. DOI:10.1038/sj.npp.1300858. PMID 16123756.